A lot of people say that the best trading route includes a run to Pax station in the Dogovor system to pick up crassworms. They're nutritious and they taste okay too! You can do this in a shuttle with fuel tanks, but you really ought to wait until you have a scoutship or a transporter. Nice and fast! Do not engage the Voinians or they will reduce you to cosmic particles.
The monks at Omm pay top dollar for crassworms, which they use in some top-secret pharmaceutical manufacturing process. Buy medical goods and head back the way you came, but stop off at Telnan in the Ariane system. Medical goods are always in demand here.
If the monks at Omm are on strike, prices soar. Fly empty to Telnan, or fly to Huron instead.
Once at Telnan, sell the medical stuff and buy equipment (at medium price, but still worth it) and take it back to Pax.
Rinse and repeat, and rinse and repeat, and rinse and repeat as required. With a full set of captured or hired freighters, you can rake in millions in minutes.
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"I wear a helmet
But I've got a bare chest
I do some talking
My phaser does the rest
Don't like your tentacles
Don't like your face
Don't like your planet
Think I'll lay it to waste
'Coz I'm Rambo in Space
Yeah, I'm Rambo in Space"