Hi,
Just read the thread (which is now closed) about OS X Panther not working with any Ambrosia games including Uplink.
I have been running Uplink in Mac OS X Panther for a while now without a problem... I am guessing that people who have experienced problems had the game before they upgraded to Panther.
Simply moving the Users folder out of the Uplink game folder and delete the Uplink game. Then reinstall from original disks or from ambrosia download (make sure you know you registration code before you do all this) The game should work fine after this.
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// cypher